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27+ min ago   (55+ words) Pembrolizumab, one of the most widely prescribed cancer immunotherapies in the world, has long been dosed on the assumption that saturating the PD-1 receptor on T cells is the key to unlocking the immune system against tumours. A new translational…...

34+ min ago   (120+ words) Adoptive T cell therapy has delivered striking remissions in some blood cancers, but its promise in solid tumors has been repeatedly undermined by a stubborn problem: the therapeutic cells do not last. Engineered T cells that flood a tumor and…...

2+ hour, 2+ min ago   (758+ words) Scientists in Japan have taken one of the most detailed looks yet at how large-scale genome disruption inside tumor cells may quietly rewire the immune landscape around them, and their findings could help explain why some cancers mount virtually no…...

4+ hour, 50+ min ago   (747+ words) For years, biologists catalogued small non-coding RNAs by counting how many of each type appeared in a sequencing run. That approach treated tiny RNA molecules as a census problem, and it worked well enough for microRNAs, the classical regulators of…...

19+ hour, 12+ min ago   (48+ words) Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune environment and strengthening anti-cancer T-cell activity in mice. Smart nanoparticles reprogram tumor immune cells to boost cancer attack Targeted lipid nanoparticles deliver mRNA to tumor-associated macrophages, reprogramming the immune…...

6+ hour, 58+ min ago   (680+ words) Natural killer cells have long been celebrated as the swift, unsung assassins of the immune system, capable of detecting and destroying tumor cells without the elaborate priming that T cells require....

10+ hour, 29+ min ago   (88+ words) One of the most lethal cancers in dogs has long frustrated veterinary oncologists with its stubborn one-size-fits-all treatment approach. Now, a research team at the University of São Paulo has shown that canine splenic hemangiosarcoma—a rapidly progressive cancer of…...

11+ hour, 21+ min ago   (83+ words) Every cell in the human body carries the same genome, yet a neuron, a hepatocyte, and an immune cell behave in utterly different ways. The difference lies in which genes are switched on, when, and where. That act of switching,…...

13+ hour, 48+ min ago   (743+ words) For more than a decade, the enzyme indoleamine 2,3-dioxygenase 1, better known as IDO1, has been one of immunology’s most tempting drug targets....

14+ hour, 47+ min ago   (616+ words) Coronaviruses depend on a remarkable transcriptional strategy known as discontinuous RNA synthesis to generate the subgenomic RNAs, or sgRNAs, that allow their relatively compact genomes to express a full complement of structural and accessory proteins....